KLF 5 ( Kruppel - like factor 5 ( intestinal ) )

نویسندگان

  • Ceshi Chen
  • Yinfa Zhou
  • Jin-Tang Dong
چکیده

KLF5 is a transcription factor. Many KLF5 target genes, such as PDGFa, PPARg, NFkB, cyclinD1, KLF4, and TCR, have been identified in different cell models. KLF5 regulates cell proliferation, cell cycle, apoptosis, and differentiation. KLF5 is an important transcription factor for cardiovascular remodeling and tumor angiogenesis. KLF5 is essential for mouse embryo development. Additionally, KLF5 may play an important role in several tumor types including breast, prostate, bladder, colon, esophagus, and skin.

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تاریخ انتشار 2011